Efficacy of two flubendazole formulations against the hydatid disease in mice

CEBALLOS, L.; ELISSONDO, M.C.; DOPCHIZ, M.; ALVAREZ, L.; SÁNCHEZ BRUNI, S.; DENEGRI, G. & LANUSSE, C.

Mar del Plata

Otro; XXXVII Reunión Anual de la Asociación Argentina de Farmacología Experimental; 2005

Asociación Argentina de Farmacología Experimental

Flubendazole (FLBZ) has been shown efficacy against protoscoleces of Echinococcus granulosus in vitro. The aim of this work was to evaluate the clinical efficacy of two FLBZ formulations of against hydatid cyst developed in mice. BalbC mice were intraperitoneally (ip) infected with E. granulosus protoscoleces (1500/animal). Nine month after infection, the mice were divided in three groups (n= 10): 1) control, untreated; 2) orally treated with a FLBZ-cyclodextrin solution; 3) orally treated with a FLBZ-carboxy-metylcellulose suspension. Groups 2 and 3  were dosed at 5 mg/kg every 12h for 25 days. After treatment, animals were euthanised and the recovered hydatid cysts were weighed and subjected to an ultrastructure study (TEM, SEM). Significantly lower weight was observed in the cyst recovered from Group 2, compared with the Group 1 (control) and Group 3. The higher efficacy achieved with the FLBZ cyclodextrin solution, may be related to a greater FLBZ bioavailability, and higher concentrations achieved at the cyst localization site.