Hexarelin affects memory acquisition in mice

CARLINI VP; MARTINI AC; VINCENTI LM; LUQUE E; PUECHAGUT P; RUIZ RD; RUBIALES DE BARIOGLIO S; FIOL DE CUNEO M

Huerta Grande, Córdoba

Jornada; XVII Jornadas Científicas de la Sociedad de Biología de Córdoba; 2009

Sociedad de Biología de Córdoba

The demonstrated stimulating effects of ghrelin (Ghr) upon memory are capable to revert the deleterious effects provoked by chronic food restriction. The objectives of the present study were to evaluate the effects of a ghrelin analogue employed in human therapy, hexarelin (HEX), upon mice memory acquisiton, employing an novel object recognition test at 1h and 24 h, in two designs: A) HEX administration (100 ó 200 ug/kg/día, sc) to adult mice for 28 days and B) HEX administration (200 ug/kg/día, sc) to pregnant females during different periods, evaluating memory acquisition in their litter at adulthood. In A, HEX diminished memory vs control group (C) in females with both doses assayed (% of time exploring novel object: C 1h: 68.5+-2.3, n=14; HEX100 24h: 36.26+-.9, n=7; HEX200 1h: 39.2+-4.7, n=8; HEX200 24h: 37.6+-3.2, n=8, p