La adenosina atenúa la disfunción postisquémica diastólica del miocardio atontado

VERONICA DANNUNZIO; MARTIN DONATO

Revista Argentina de Cardiología

Editorial Stilman-Favieri

Lugar: Buenos Aires; Año: 2001 vol. 69 p. 198 - 203

0034-7000

RESUMEN: There is experimental evidence that adenosine, administered only in the reperfusión period, attenuates systolic alterations of the postischemic ventricular dysfunction. Nevertheless, it is not clear if this protection extends on the diastolic dysfunction. The objective was to determine if the adenosine, administered during the reperfusión, attenuates the diastolic alterations presents after 15 minutes of global ischemia and an additional objective was to determine the possible participation of A1 receptors acting as a mediators of the above mentioned effects. Isolated and isovolumic rabbit hearts, were perfuse according to the Langendorff technique, and subjected to 15 minutes of global ischemia and 30 minutes of reperfusion. Using a pressure transducer we registering the left intraventricular pressure and the coronary perfusion pressure (CPP). We measured, the left ventricular end diastolic pressure (diastolic stiffness), and the CPP. We calculated the ratio between +dP/dtmáx and -dP/dtmáx and the constant of time of decay of the pressure during the isovolumic relaxation (tau, t). The adenosine administered from the beginning of the reperfusión attenuated the increase of the diastolic stiffness, without modifying the early alterations of the isovolumic relaxation.