INVESTIGADORES
GOLDSTEIN RAIJ Jorge
artículos
Título:
Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta.
Autor/es:
DAMIANO A, ZOTTA E, GOLDSTEIN J, REISIN I, IBARRA C.
Revista:
PLACENTA
Editorial:
W.B. Saunders
Referencias:
Año: 2001 vol. 22 p. 776 - 781
ISSN:
0143-4004
Resumen:
The syncytiotrophoblast of human term placenta (HST) is a continuous,
multinucleated structure with minimal tight junctions, which results
from the fusion of the underlying cytotrophoblast cells. Consequently,
the transport of metabolites, ions and water from mother to fetus could
take place primarily via transcellular routes. Transcellular water flux
may be facilitated by aquaporins, membrane proteins functioning as
water channels that are widely expressed in cells and tissues. Here, we
report the presence of AQP3 and AQP9 in the apical membranes of HST
using RT-PCR, immunoblotting and immunohistochemistry. Since AQP3 is
not only a water channels, but also permits the rapid passage of both
urea and glycerol, while AQP9 also mediates the passage of carbamides,
polyols, purines, and pyrimidines, we have speculated that these
proteins could be involved in the transport of water and solutes from
mother to fetus. Copyright 2001 Harcourt Publishers Ltd.