Gallbladder cancer in Salta: epidemiology, risk factors and profile k-Ras gene alteration

SAUCEDO C.

MEDICINA (BUENOS AIRES)

MEDICINA (BUENOS AIRES)

Lugar: Buenos Aires; Año: 2016 vol. 76

0025-7680

Gallbladder cancer (GBC) has unique characteristics in Argentina; large differences in terms of age-standardized-mortality rates (ASMR) due to this tumor type have been reported for the NW region of the country (8-9/105 women/ year) respect to the eastern Pampeana region (1.4/105 women/ year). Moreover, the profile of abnormalities of key genes such as kRAS and TP53 in gallbladder cancer seems to differ worldwide. We surveyed the clinical records of the San Bernardo hospital, the main health institutions in Salta city, looking for information about the epidemiology of GBC. A total of 8,135 patients were operated for different gallbladder pathologies during the period 2006-2015. Among them 83 (1.02%) were diagnosed with GBC, and the vast majority were women. The mean age of the patients at the time of diagnosis was 61 years. Cholelithiasis constitutes the major risk factor for GBC, and the composition of the gallstones seems to be related to nutritional habits.