Dosimetry Optimization System and Integrated Software (DOSIS): a comparison against FLUKA code results over a standard phantom

PEDRO P'EREZ; FRANCESCA BOTTA; FRANCISCO MALANO; MAURO VALENTE

MONTEVIDEO

Congreso; X - LATIN AMERICAN SYMPOSIUM OF NUCLEAR PHYSICS AND APPLICATIONS; 2013

COM LATINOAMERICANA DE FISICA - JEFFERSON LAB USA - UNIV. REPUBLICA URUGUAY

Dual-imaging facilities (PET-CT, SPECT-CT) allow obtainance of both mass andactivity patient-specific distributions perfectly correlated, which may improve dosedistributions estimations and radioimmunotherapy treatment planifications accuracy [1].Calculation methods at voxel level require both quantitative and qualitative validationto obtain improvements in patient-specific dosimetry [2]. This work presents advances ofa novel computational tool dedicated to 3D patient-specific dosimetry at voxel level.Focusing on providing a dosimetric tool at voxel level, as well as the development of aplatform based on full-stochastic methods for alpha-, beta- and gamma-emitters used inradiopharmaceutical applications. DOSIS is based on the Boltzmann radiation transportequation to realize energy delivering calculations. Procedures have been designed tackinginto account MIRD formalism and standards [3]. Anatomic and metabolic images, anddose maps resulting of this calculations are analysed and procesed by a special developedand designed software [4].Finally, a dose calculation over a standard phantom is performed using DOSIS calculationcode and FLUKA, validating the radiation transport code of DOSIS.[1] Y. Berker et al. Activity quantification combining conjugate-view planar scintigra-phies and SPECT/CT data for patient-specific 3-D dosimetry in radionuclide therapy.Eur J Nucl Med Mol Imaging. 2011; 38(12):2173-2185.[2] G. Sgouros. Dosimetry of Internal Emitters. J Nucl Med. 2005; 46(1):18S-27S.[3] W.E. Bolch et al. MIRD Pamphlet No. 17: The Dosimetry of Nonuniform ActivityDistributions-Radionuclide S Values at the Voxel Level. J Nucl Med. 1999; 40:11S-36S.[4] P. P ́erez et al. Dosimetry for Beta-Emitter Radionuclides by Means of Monte CarloSimulations. 12 Chapter on Nuclear Medicine. Intech. 2010.