1H NMR Spectroscopy and MR Imaging with Hyperpolarised Substances

DIRK GRAAFEN; EBERT SANDRO; OLIVER NEUDERT; LISANDRO BULJUBASICH; MARÍA BELÉN FRANZONI; JAN FALK DECHENT; KERSTIN MÜNNEMANN

Annual Reports on NMR Spectroscopy

Graham Webb

Año: 2014; p. 1 - 257

Despite their wide applicability in natural sciences, NMR and MRI still suffer from their inherently low sensitivity. This can be overcome by hyperpolarisation techniques, such as parahydrogen-induced polarisation and dynamic nuclear polarisation. Here, we focus on the generation of 1H-hyperpolarised substances with both methods. We especially address the severe lifetime issue of the accomplished 1H hyperpolarisation by demonstrating the production of hyperpolarised liquids in a continuous flow fashion and the storage of hyperpolarisation in slowly relaxing singlet states. Another problem of hyperpolarised proton NMR and MRI is the generation of contrast between a small amount of hyperpolarised molecules and a vast thermal background signal. In this contribution, we show the possibility to use the special signal pattern that is inherent to the hyperpolarisation method to generate excellent MRI contrast which may open up unprecedented opportunities to use the standard MRI nucleus 1H, for example, biomedical applications in future.