IFEG 20353
INSTITUTO DE FISICA ENRIQUE GAVIOLA
Unidad Ejecutora - UE
artículos
Título:
Why does GM1 induce a potent beneficial response to experimental Chagas disease?
Autor/es:
S. COSSY ISASI; C.A. CONDAT; G.J. SIBONA
Revista:
HFSP Journal
Editorial:
HFSP Publishing
Referencias:
Año: 2009 vol. 3 p. 142 - 151
ISSN:
1955-2068
Resumen:
Being one of the worlds neglected diseases, Chagas has neither a vaccine nor a satisfactory therapy. Inoculation of murine models with the ganglioside GM1 has shown a strikingly nonlinear effect, leading to a strong decrease in parasite load at low doses but reverting to a load increase at high doses. Cardiocyte destruction concomitant with the disease is also significantly reduced by a moderate application of GM1. A mathematical model for the interaction between the parasite and the immune system is shown to explain these effects and is used to predict an optimal dosage that maximizes parasite removal with minimal cardiocyte destruction.
