IFEG   20353
INSTITUTO DE FISICA ENRIQUE GAVIOLA
Unidad Ejecutora - UE
artículos
Título:
Interpretation of molecular dynamics on different time scales in unilamellar vesicles using field-cycling NMR relaxometry
Autor/es:
CARLA J. MELEDANDRI; JOSEFINA PERLO; EZEQUIEL FARRHER; DERMOT F. BROUGHAM; ESTEBAN ANOARDO
Revista:
JOURNAL OF PHYSICAL CHEMISTRY B - (Print)
Editorial:
AMER CHEMICAL SOC
Referencias:
Año: 2009 p. 15532 - 15540
ISSN:
1520-6106
Resumen:
Fast field-cycling (FFC) and rotating-frame nuclear magnetic resonance
relaxometry were used to study molecular and collective dynamics in
unilamellar liposome systems. Relaxation data for liposomes of diameter
about 100 nm composed of 1,2-dimyristoyl-sn-glycero-3-posphocholine (DMPC) or 1,2-dioleoyl-sn-glycero-3-posphocholine
(DOPC) were obtained. The Larmor frequency dependence of the
spin−lattice relaxation rates was interpreted in terms of clearly
defined relaxation mechanisms associated with the underlying molecular
dynamics. The physical parameters obtained from the analysis are
consistent with values available in the literature obtained from a
range of experimental techniques. This work establishes the potential
of our approach to study dynamics in liposomal samples of more complex
lipid composition.