Highly Stable Graphene Oxide-Gold Nanoparticle Platforms for Biosensing Applications

SAUCEDO-OROZCO, IZCOATL; BITTENCOURT, CARLA; VILLABONA LEAL, EDGAR GIOVANNY; PÉREZ, ELÍAS; HERNÁNDEZ-SÁNCHEZ, DANIA; BRACAMONTE, VICTORIA; QUINTANA, MILDRED

PHYSICAL CHEMISTRY CHEMICAL PHYSICS

ROYAL SOC CHEMISTRY

Lugar: CAMBRIDGE; Año: 2017

1463-9076

Graphene oxide-gold nanoparticle (AuNP@GO) hybrids were fabricated in water dispersions of graphene oxide (GO) and Au precursor completely free of stabilizing agents by UV-light irradiation. Gold nanoparticles (AuNP) nucleation, growth, and stabilization mechanisms at the surface of GO are discussed on the basis of UV-Vis, Raman, IR, and X-Ray photo-spectroscopy studies. The analyses of AuNP@GO hybrids by transmission electron microscopy (TEM), thermo gravimetric (TGA) and electrochemical tests exhibit outstanding chemical, thermal and electrochemical stabilities. Thus, AuNP@GO biosensing platforms were fabricated for surface enhanced Raman spectroscopy (SERS) detection of Crystal Violet (CV) a SERS standard molecule, and in a different set of experiments, for flavin adenine dinucleotide (FAD) a flavoprotein coenzyme that plays an important role in many oxidoreductase and reversible redox conversions in biochemical reactions. AuNP@GO hybrids synthesized by using UV light irradiation show exceptional stability and high intensification of the Raman signals exhibiting high potential as biomedical probes for detection, monitoring, and diagnosis of medical diseases.