IFEG 20353
INSTITUTO DE FISICA ENRIQUE GAVIOLA
Unidad Ejecutora - UE
artículos
Título:
Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld Method
Autor/es:
L. S. BERNARDI; F. B. FERREIRA; S. CUFFINI; C. E. MADURO DE CAMPOS; G. A. MONTI; G. KUMINEK; P. R. OLIVEIRA; S. G. CARDOSO
Revista:
TALANTA
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 117 p. 189 - 195
ISSN:
0039-9140
Resumen:
Venlafaxine hydrochloride(VEN)isanantidepressantdrugwidelyusedforthetreatmentofdepression. The purposeofthisstudywastocarryoutthepreparationandsolidstatecharacterizationofthepure polymorphs (Forms1and2)andthepolymorphicidentification andquantification offourcommercially- availableVENrawmaterials.Thesetwopolymorphicformswereobtainedfromdifferentcrystallization methods andcharacterizedbyX-rayPowderDiffraction(XRPD),DiffuseReflectance InfraredFourier Transform(DRIFT),RamanSpectroscopy(RS),liquidandsolidstateNuclearMagneticResonance(NMR and ssNMR)spectroscopies,DifferentialScanningCalorimetry(DSC),andScanningElectronMicroscopy (SEM) techniques.ThemaindifferenceswereobservedbyDSCandXRPDandthelatterwaschosenas the standardtechniquefortheidentification andquantification studiesincombinationwiththeRietveld method forthecommercialrawmaterials(VEN1?VEN4) acquiredfromdifferentmanufacturers. AdditionallyForm1andForm2canbeclearlydistinguishedfromtheir 13C ssNMRspectra.Through the analysis,itwaspossibletoconcludethatVEN1andVEN2werecomposedonlyofForm1,whileVEN3 and VEN4wereamixtureofForms1and2.Additionally,theRietveldrefinement wassuccessfully applied toquantifythepolymorphicratioforVEN3andVEN4.
