IIIE   20352
INSTITUTO DE INVESTIGACIONES EN INGENIERIA ELECTRICA "ALFREDO DESAGES"
Unidad Ejecutora - UE
artículos
Título:
New horizons for the in vivo assessment of major aspects of bone quality: Microstructure and material properties assessed by Quantitative Computed Tomography and Quantitative Ultrasound methods developed by the BioAsset consortium
Autor/es:
C.-C. GLÜER; M. KRAUSE; O. MUSEYKO; B. WULFF; G. CAMPBELL; T. DAMM; M. DAUGSCHIES; G. HUBER; Y. LU; J. PEÑA; S. WALDHAUSEN ; J. BASTGEN; K. ROHDE; S. BREER; I. STEINEBACH; F. THOMSEN; M. AMLING; R. BARKMANN; K. ENGELKE; M. MORLOCK; J. PFEILSCHIFTER; K. PÜSCHEL
Revista:
OSTEOLOGIE
Editorial:
VERLAG HANS HUBER
Referencias:
Lugar: Stuttgart; Año: 2013 vol. 22 p. 169 - 248
ISSN:
1019-1291
Resumen:
The Biomechanically founded individualised osteoporosis Assessment and
treatment (BioAsset) consortium pursues experimental and clinical
studies in the context of skeletal effects of bisphosphonate treatment.
Here, first results using newly developed diagnostic methods in a set of
vertebral bone specimen obtained from donors with documented
bisphosphonate history ranging from 0 to more than 5 years of treatment
are presented. A new thoracolumbar quantitative computed tomography
(QCT) protocol covering T6 to L4 plus high-resolution QCT (HRQCT)
assessment of T12 were compared with high-resolution peripheral QCT
(HRpQCT) and micro-CT scans of excised specimens serving as gold
standard techniques. Finite element (FE) modelling was performed.
Material, ultrastructural, and micromechanical properties were tested on
a set of single trabeculae obtained from the donor specimens. A newly
developed quantitative ultrasound (QUS) device for measuring the
anisotropy of cortical material properties at the tibia was designed and
built. The thoracolumbar QCT protocol permitted in situ imaging with
good image quality and automated segmentation of vertebral bodies in the
whole range from T6 to L4. The duration of bisphosphonate treatment was
significantly associated with increased levels of mineralization and
this effect could be measured with HRQCT performed on excised specimens.
Microstructural parameters contributed to vertebral bone strength
modelled by FE analysis independently of bone mineral density. The new
QUS tibia scanner permitted measuring the acoustical anisotropy of
reference materials. Taken together, these results document that new
methods developed in BioAsset permit a more comprehensive assessment of
bone fragility. The set of donor specimens with a documented history of
bisphosphonate treatment allows for the assessment of the effects of
long-term treatment from the organ down to the tissue and material
level. These results will ultimately be linked to the parallel clinical
study to provide guidance for determining the optimum duration of
bisphosphonate treatment to reduce the incidence of osteoporotic
fractures.