INVESTIGADORES
SALVADOR Gabriela Alejandra
congresos y reuniones científicas
Título:
COX-2 REGULATION BY 1α,25(OH)2 D3 -VDR LIGAND IN ENDOTHELIAL CELLS EXPRESSING vGPCR
Autor/es:
TAPIA, C; SUARES, A; SALVADOR, G; GONZALEZ PARDO, V
Lugar:
Buenos Aires
Reunión:
Congreso; LIII Reunión Anual de la Sociedad Argentina de Investigación en Bioquímica y Biología Molecular (SAIB)- Reunión Conjunta de Sociedades de Biociencias; 2017
Institución organizadora:
Sociedades de Biociencias Argentina
Resumen:
(98) COX-2 REGULATION BY 1α,25(OH)2D3-VDR LIGANDIN ENDOTHELIAL CELLS EXPRESSING vGPCRCinthya Tapia (1), Alejandra Suares (1), Gabriela AlejandraSalvador (2), Veronica Gonzalez Pardo (1)(1) INBIOSUR-DBByF-Universidad Nacional del Sur. (2) INIBIBB-UniversidadNacional del Sur.The Kaposi?s Sarcoma-associated Herpes virus G Protein-CoupledReceptor (vGPCR) is a key molecule in the pathogenesis ofKaposi Sarcoma. 1α,25(OH)2D3 anti-proliferative impact in vGPCRcells occur in part by NF-κB pathway negative modulation,family of conserved transcription factors critical during the inflammatoryresponse. In this work, we studied if COX-2 modulation by1α,25(OH)2D3 in vGPCR cells contributes to the anti-inflammatoryaction. As we have previously reported vGPCR cell proliferation is
