Phosphatidic acid mediates neurofilament loss induced by α-synuclein?

CONDE, MELISA A.; ALZA, NATALIA P.; URANGA ROMINA; SALVADOR, G.A.

Buenos Aires

Congreso; . LIII Reunión Anual de la Sociedad Argentina de Investigación en Bioquímica y Biología Molecular (SAIB)- Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedades de Biociencias Argentina

(449) PHOSPHATIDIC ACID MEDIATES NEUROFILAMENTLOSS INDUCED BY α-SYNUCLEINMelisa Conde (1), Natalia Alza (2), Romina Uranga (1), GabrielaSalvador (1)(1) INIBIBB-CONICET; Departamento de Biología, Bioquímicay Farmacia-UNS. (2) INIBIBB-CONICET; Departamentode Química-UNS.In our laboratory, we have previously studied the role of phospholipase-mediatedsignaling in different models of neuronal injury.In this work, our aim was to characterize the effect of wild typeα-synuclein (WT α-syn) overexpression on phospholipase D (PLD)pathway in a human neuroblastoma cell line. Immunocytochemistryshowed a significant decrease in the neuronal marker neurofilament(NF) expression and a rise in F-actin foci in WT α-syn cells comparedwith control cells (pcDNA3) (p