Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome

ZAMBERNARDI, AGUSTINA; GONDOLESI GABRIEL; CABANNE, ANA; MARTINEZ MARIA INÉS; SOLAR HECTOR; MARTIN RUMBO; CAROLINA RUMBO

CLINICAL TRANSPLANTATION

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2013 p. 137 - 142

0902-0063

Exfoliative rejection is a severe complication after intestinal transplant. The assessment of mucosa histology is restricted to the area reached by endoscopy. We aim to evaluate the serum albumin value as a parameter of graft damage and clinical prognosis in intestinal exfoliative rejection (ExR). The present study is a retrospective analysis of 11 episodes of ExR occurred in a cohort of 26 patients. Serum albumin levels were measured twenty four hours after diagnosis and twice a week thereafter and then correlated with parameters of clinical and graft histological recovery. During ExR all patients had very low serum albumin levels, reaching a minimum average of 1.9 +/- 0.3 g/dl. According to the value of albumin levels at ExR diagnosis, the patients were grouped finding a correlation with their clinical evolution. Six ExR episodes presented with severe hipoalbuminemia (