INVESTIGADORES
RUMBO Martin
artículos
Título:
Mucosal innate response stimulation induced by lipopolysaccharide protects against Bordetella pertussis colonization.
Autor/es:
ERREA AGUSTINA; GRISELDA MORENO; FEDERICO SISTI; JULIETA FERNANDEZ; M RUMBO; DANIELA HOZBOR
Revista:
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
Editorial:
SPRINGER
Referencias:
Año: 2010 p. 103 - 108
ISSN:
0300-8584
Resumen:
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Non specific enhancement of the
airways innate/inflammatory response has been shown to impair lung infections
in several models of infection such diverse as influenza A, Streptococcus pneumoniae and Aspergillus niger. Our aim was to evaluate
if a similar event could operate in the context of Bordetella pertussis infection, in spite of the variety of
mechanisms that this pathogen has developed to subvert host response. Using a B. pertussis intranasal infection model
and coadministration of different TLR agonists at the moment of the infection
we observed that the enhancement of innate response activation, in a TLR4
dependent way, could efficiently impair B.
pertussis colonization (p<0.001). Flagellin or poly I:C
codaministration, in spite of inducing expression of innate response markers
TNFα, CXCL2 and IL6, was not effective to prevent bacterial colonization. LPS
from different microbial sources were equally effective to B. pertussis LPS in promoting this effect, that was not observed in
TLR4 deficient mice strains.
Our results indicate that specific
antimicrobial mechanisms triggered by TLR4 stimulation are able to impair B. pertussis colonization; beyond the activity of its known virulence factors.
These findings could complement our current view of the role of TLR4 dependent
processes that contribute to anti-pertussis immunity.
