Polymorphism in a new ciprofloxacin saccharinate: X-Ray, FTIR and Solid State NMR characterization

C. ROMAÑUK; Y. GARRO LINCK; A.K CHATTAH; G.A. MONTI; R. BAGGIO; M.T. GARLAND; S.L. CUFFINI; R.H. MANZO; M.E. OLIVERA

Estancia San Pedro, San Pablo

Simposio; LAPOLC 09 - II Latin-American Symposium on Polymorphism and Crystallization in Drugs and Medicines; 2009

 A new polymorphic form of Ciprofloxacin saccharinate (CIP-SAC form II) was obtained in a single crystal form. The product was characterized, and compared with our previously reported form I. To distinguish both polymorphic forms we used X-ray powder diffraction, single-crystal X-ray diffraction, Infrared and Solid State NMR (13C-CPMAS). DSC/TGA showed that the reaction between precursors is complete and the crystals are obtained with a high degree of purity. Both forms I and II are obtained as salts, as can be observed from the FTIR spectroscopy. Powder X-ray diffraction and 13C CP-MAS allow distinguishing the two polymorphic forms. Single crystal X-ray diffraction of form II accounted for inter and intra molecular interactions which could be extrapolated to form I.