Furosemide:Maltodextrin interactions studied using NMR

C. GARNERO; M. LONGHI; A. K. CHATTAH

Alta Gracia

Workshop; Magnetic Resonance in a Cordubensis Perspective; 2011

Grupo de RMN Lanais-FaMAF e ISMAR

Furosemide (FUR) is a loop diuretic used in the oral treatment of edematous states, which has seven polymorphic forms. FUR is practically insoluble in water therefore increased their solubility is particularly important because its bioavailability is related to in vivo dissolution profile. Maltodextrins (MDs), obtained from the partial hydrolysis of food grade starch with suitable acids and/or enzymes, have the capability of complexation to various compounds, with the host-guest one being the most common interaction. Considering that a strategy widely used to increase the solubility of drugs is the complex formation, this work is focused to investigate the interaction of two polimorphs of FUR (I and II) with MD in solution and solid state, in order to provide an increasing in their solubility.