INVESTIGADORES
CHATTAH Ana Karina
artículos
Título:
Improving the Stability and the Pharmaceutical Properties of Norfloxacin Form C Through Binary Complexes with beta-cyclodextrin
Autor/es:
CLAUDIA GARNERO; ANA K. CHATTAH; CAROLINA ALOISIO; LUIS FABIETTI; MARCELA LONGHI
Revista:
AAPS PHARMSCITECH
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2018
ISSN:
1530-9932
Resumen:
Norfloxacin, an antibiotic existing that exist in different solid forms, has very unfavorable properties in terms of solubility and stability. Binary complexes of Norfloxacin, in the solid form C, and beta-cyclodextrin were procured by the kneading method and physical mixture. Their effect on the solubility, the dissolution rate, and the chemical and physical stability of the Norfloxacin wereas evaluated. To perform stability studies, the solid samples were stored under accelerated storage conditions, for a period of 6 months. Physical stability was monitored through powder X-ray diffraction, high resolution 13C solid-state nuclear magnetic resonance and scanning electron microscopy. The results showed evidence that the kneaded complex increased and modulated the dissolution rate of Norfloxacin C. Furthermore, it was demonstrated that the photochemical stability was increased in the complex, without affecting its physical stability. The results points to the conclusion that the new kneading complex of Norfloxacin constitutes an alternative tool to formulate a potential oral drug delivery system with improve oral bioavailability.