Oleoylethanolamide attenuates cocaine-induced behaviours through a ppará receptor-independent mechanism

BLANCO, E1,2,3, BILBAO A4, LUQUE-ROJAS MJ2, SUÁREZ J2, GALEANO P3, CAPANI F, SPANAGEL R1, RODRÍGUEZ DE FONSECA

Cordoba

Congreso; Congreso Sociedad Argentina de Neurociencias; 2012

Oleoylethanolamide (OEA) is an acylethanolamide that acts as an agonist of PPARá nuclear receptor to exert their biological functions, such as feeding and metabolism. Moreover, recent evidence suggests that OEA participates in the control of reward-related behaviours. However, the role of OEA-PPARá interaction in drug-mediated behaviours is still unknown. In the present work, we studied the role of OEA and PPARá on psychomotor and rewarding effects of cocaine using behavioural tests that feature core components of addiction. Results showed that an acute administration of OEA reduces spontaneous locomotion and attenuates psychomotor activation triggered by cocaine. However, PPARá receptor knockout mice showed normal sensitization to cocaine, despite the fact that OEA was able to reduce behavioural sensitization. Furthermore, CPP and reinstatement to cocaine were intact in these mice. Our results indicate that PPARá receptor has not a critical, if any, role mediating psychomotor and rewarding effects of cocaine. Thus, further research is needed to identify OEA targets that mediate its inhibitory action on cocaine-mediated responses. .