Oxidative Medicine in Brain Injury.

MATILDE OTERO LOSADA, FRANCISCO CAPANI

CURRENT PHARMACEUTICAL DESIGN.

BENTHAM SCIENCE PUBL LTD

Año: 2019

1381-6128

suggesting potential neuroprotective strategies, only scattered data are available from clinical studies. In this regard, a few candidate neuroprotectants have been little studied in connection with their antioxidant, antiapoptotic, anti-excitotoxic, immunomodulatory, and neurotrophic effects.In parallel with clinical innovations, preclinical research initiatives are also identifying new animal models that more closely resemble the clinical course and pathology of neurodegenerative diseases.In order to define new therapeutic targets, it is important to clarify the specific mission of the brain cells involved in damage/repair system in the examined animal models. Moreover, considering that after hypoxic damage, detrimental events like excitotoxicity, pro-apoptosis, pro-inflammatory reaction, and others, intermingle with the repairing events in both time- and cellular-dependent fashion. In addition, to improve translational research from the experimental data to its clinical application, identifying more reliable post hypoxia brain markers is mandatory to design and develop potential therapeutic interventions according with the follow-up time after the hypoxic episode.Thus, deeper understanding of the precise participation of neurons, glia, and endothelial cells by contrasting and comparing the outcome of studies using animal versus cellular models might be expected to provide more clues to design new therapeutic strategies for reducing the current gap among the experimental and the clinical data. One of the main issue should to study the epigenetic mechanism of neuroprotective agents and their action on the genetic modification induced by hypoxia. We think that to reach this objective is critical to obtain more conclusive results in patients that at the moment don?t have any appropriate therapy for mitigating the several diseases generated by brain hypoxia. Although same interesting approaches are underway future studies are necessary to elucidate novel mechanism of neuroprotection