) Immune mediated inflammation promotes subclinical atherosclerosis in recent-onset psoriatic arthritis patients without conventional cardiovascular risk factors

) IMMUNE MEDIATED INFLAMMATION PROMOTES SUBCLINICAL ATHEROSCLEROSIS IN RECENT-ONSET PSORIATIC ARTHRITIS PATIENTS WITHOUT CONVENTIONAL CARDIOVASCULAR RISK FACTORS

Frontiers in Immnology

Frontiers

Lugar: Berna; Año: 2018

1664-3224

Studies on the inflammatory burden in recent-onset psoriatic arthritis (PsA) patientswithout conventional cardiovascular risk factors (CVRFs) are not available. This preliminarystudy focuses on cardiovascular risk in cutaneous psoriasis (CPs) and recent-onsetPsA patients. Blood biochemistry (glucose, cholesterol, uric acid, lipid profile and apolipoproteinB) was analyzed using standard kits. Proatherogenic inflammation markers,C-reactive protein (CRP) and interleukin-6 (IL-6), and endothelial activators monocytechemoattractant protein-1 (MCP-1) and soluble intercellular adhesion molecule-1(sICAM-1), were determined by enzyme-linked immunosorbent assay. Ultrasoundimages allowed measuring carotid intima?media thickness (cIMT). Our study firstshows an increase in cIMT, and in serum levels of sICAM-1 and CRP in recent-onsetPsA patients not presenting conventional CVRFs over the non-medicated time-period,from disease diagnosis to the beginning of pharmacological treatment, compared withhealthy subjects. The outcome highlights the importance of monitoring serum level ofsICAM1, CRP, and cIMT, and the value of primary prevention in psoriatic patients evenwith no history of cardiovascular events.