Chronic consumption of ethanol has a damaging effect in various organs and metabolic functions, including liver, kidney, heart, pancreas, and brain (Sun and Sun, 2001; Bezerra Rde et al., 2005). Additionally, it has been shown that both the acute and chro

GEORGEE.BARRETO, FRANCISCO CAPANI, RICARDOCABEZAS1

Front. Aging Neurosci.

Index Copernicus

Año: 2014 p. 1 - 4

Chronicconsumptionofethanolhasadamagingeffectinvariousorgansandmetabolic functions,includingliver,kid-ney,heart,pancreas,andbrain(SunandSun,2001;BezerraRdeetal.,2005).Additionally,ithasbeenshownthatboththe acuteandchronicethanolintakeinducealterationinvoltage-gatedchan-nels causingbehavioralandelectrophysio-logicalchangesinthebrain(Little, 1999).Inthelastfewyears,theeffectofethanolin theelectrophysiologicalphenomenon,knownascorticalspreadingdepression(CSD), hasbeenwidelyassessed(Sonnand Mayevsky,2001;BezerraRdeetal.,2005; Abadie-Guedesetal.,2008) asanimportantmodeltopredictthedamagingeffects ofethanolinbothyoungandagedbrains.