INVESTIGADORES
GLEISER Raquel Miranda
artículos
Título:
One-pot microwave assisted synthesis and structural elucidation of novel ethyl 3-substituted-7-methylindolizine-1-carboxylates with larvicidal activity against Anopheles arabiensis
Autor/es:
CHANDRASHEKHARAPPA, SANDEEP; VENUGOPALA, KATHARIGATTA N.; NAYAK, SUSANTA K.; M. GLEISER, RAQUEL; GARC√ćA, DANIEL A.; KUMALO, HEZEKIEL M.; KULKARNI, RASHMI S.; MAHOMOODALLY, FAWZI M.; VENUGOPALA, RASHMI; MOHAN, MAHENDRA K.; ODHAV, BHARTI
Revista:
JOURNAL OF MOLECULAR STRUCTURE
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2018 vol. 1156 p. 377 - 384
ISSN:
0022-2860
Resumen:
In the present investigation a series of novel ethyl 3-substituted-7-methylindolizine-1-carboxylates was achieved by microwave assisted one-pot method. The purity of the compounds was ascertained by HPLC and structural elucidation of the title compounds was achieved by FT-IR, NMR (1H and 13C), LC-MS and elemental analysis. One randomly selected compound from the series was further studied by single crystal X-ray method for intra and intermolecular interactions. Larvicidal properties of the characterized compounds were evaluated against Anopheles arabiensis and it was found that indolizine pharmacophore influences larvicidal activity as we can see larvicidal activity for all the analogues. The synthesized analogues (2j, 2m and 2f) were the most potent compounds based on the functional groups on the indolizine pharmacophore for larvicidal assay.