INVESTIGADORES
ALOVERO Fabiana De Lujan
artículos
Título:
Mode of action of sulphanilyl fluoroquinolones (NSFQs)
Autor/es:
FABIANA L. ALOVERO Ó F. L. ALOVERO; MARCELO J, NIETO; THEN RUDOLF,; MARÍA ROSA, MAZZIERI; RUBEN HILARIO, MANZO
Revista:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Editorial:
AMER SOC MICROBIOLOGY
Referencias:
Año: 1998 vol. 42 p. 1495 - 1498
ISSN:
0066-4804
Resumen:
The mode of action of sulfanilyl fluoroquinolones (NSFQs) was investigated with NSFQ-104, NSFQ-105, and some structurally related compounds. Evidence arising from interactions with p-aminobenzoic acid and trimethoprim suggested that a sulfonamidelike mechanism of action makes little or no contribution to the in vitro activity of NSFQs. NSFQ-105 showed an activity that inhibits gyrase-catalyzed DNA supercoiling that is similar to the activity of other fluoroquinolones. Also, NSFQ-105 uptake was decreased by the presence of Mg2+ and increased by a lower pH. These results indicate that NSFQs having only one ionizable group could exhibit more favorable kinetics of access to the bacterial cell than zwitterionic fluoroquinolones.
