Growth hormone modulation of hepatic epidermal growth factor receptor signaling

GONZÁLEZ LORENA; DÍAZ MARÍA EUGENIA; MIQUET JOHANNA G; SOTELO ANA ISABEL; DOMINICI, FERNANDO P

TRENDS IN ENDOCRINOLOGY AND METABOLISM

ELSEVIER SCIENCE LONDON

Lugar: Londres; Año: 2021 vol. 32 p. 403 - 414

1043-2760

Epidermal growth factor receptor (EGFR) signaling has a central role in the regenerative response of the liver upon injury and is involved in cellular transformation linked with chronic damage. Hepatic EGFR expression, trafficking and signaling is regulated by growth hormone (GH). Chronically elevated GH levels are associated with liver cancer development and progression in mice. Studies performed in different in vivo experimental models indicate that EGF and GH mutual regulation is complex. Several factors, such as the lapse of exposure to supraphysiological GH levels as well as the pattern of administration of GH, appear as important variables to be considered in the exploration of the interplay between these two hormones in connection with the progression of hepatic tumors.