Growth hormone (GH)/STAT5 signaling during the growth period in liver of mice overexpressing GH

MARTINEZ CAROLINA S, PIAZZA VERÓNICA G, RATNER LAURA D, MATOS MARINA N, GONZÁLEZ LORENA, RULLI SUSANA B, MIQUET JOHANNA G, SOTELO ANA I.; PIAZZA VERÓNICA G; DÍAZ MARÍA EUGENIA; BOPARAI RAVNEET K; ARUM OGE; RAMÍREZ MARÍA CECILIA; GONZÁLEZ LORENA; BECÚ-VILLALOBOS DAMASIA; BARTKE ANDRZEJ; TURYN DANIEL; MIQUET JOHANNA G; SOTELO ANA ISABEL

JOURNAL OF MOLECULAR ENDOCRINOLOGY

BIOSCIENTIFICA LTD

Lugar: Bristol; Año: 2015

0952-5041

Growth hormone (GH)/STAT5 signaling is desensitized in liver of adult transgenic mice overexpressing GH; however, these animals present greater body size. To assess if the STAT5 pathway is active during the growth period in liver of these animals, and how signaling modulators participate in this process, growing transgenic mice and normal siblings were evaluated. STAT5 does not respond to an acute GH-stimulus but presents higher basal phosphorylation in liver of growing GH-overexpressing mice. GH receptor and positive modulators GR and HNF1 display greater abundance in transgenic animals, supporting STAT5 activity. Negative modulators CIS and PTP1B are increased in GH-overexpressing mice. Suppressors SOCS2 and SOCS3 exhibit higher mRNA levels in transgenic mice but lower protein content, suggesting they are being degraded. Therefore, STAT5 signaling is increased in liver of GH-transgenic mice during the growth period, with a balance between positive and negative effectors resulting in an accelerated but controlled growth.