Exposure to growth hormone is associated with hepatic up-regulation of cPLA2α and COX

PIAZZA, VERÓNICA G.; MATZKIN, MARÍA E.; CICCONI, NADIA S.; MUIA, NADIA V.; VALQUINTA, SOFÍA; MCCALLUM, GREGORIO J.; MICUCCI, GIANNINA P.; FREUND, THOMAS; ZOTTA, ELSA; GONZÁLEZ, LORENA; FRUNGIERI, MÓNICA B.; FANG, YIMIN; BARTKE, ANDRZEJ; SOTELO, ANA I.; MIQUET, JOHANNA G.

MOLECULAR AND CELLULAR ENDOCRINOLOGY.

ELSEVIER IRELAND LTD

Año: 2020 vol. 509

0303-7207

Continuously elevated levels of growth hormone (GH) during life in miceare associated with hepatomegaly due to hepatocytes hypertrophy andhyperplasia, chronic liver inflammation, elevated levels of arachidonic acid (AA) at young ages and liver tumors development at old ages. In this work, the hepatic expression of enzymes involved in AA metabolism, cPLA2α, COX1 and COX2 enzymes, was evaluated in young and old GH-transgenic mice. Mice overexpressing GH exhibited higher hepatic expression of cPLA2α, COX1 and COX2 in comparison to controls at young and old ages and in both sexes. In old mice, when tumoral and non-tumoral tissue were compared, elevated expression of COX2 was observed in tumors. In contrast, exposure to continuous lower levels of hormone for a short period affected only COX1 expression in males. Considering the role of inflammation during livertumorigenesis, these findings support a role of alterations in AA metabolism inGH-driven liver tumorigenesis.