A CORNEAL INJURY IN ONE EYE LEADS TO DISRUPTION OF MUCOSAL TOLERANCE IN THE OPPOSITE OCULAR SURFACE THROUGH A TRPV1- AND SUBSTANCE P-DEPENDENT NEUROINFLAMMATORY CIRCUIT

MIGLIO RODRIGUEZ M; GUZMAN M; KEITELMAN I; SABBIONE F; TREVANI AS; GIORDANO M; GALLETTI J

Congreso; Reunión Conjunta de Sociedades de Biociencias.; 2017

Both ocular surfaces are considered functionally independent,thus an injury to one cornea is not expected to affect the oppositeeye. However, we have observed that the tolerogenic immune response observed in mice after exposing one ocular surface to a foreign antigen is prevented if the opposite cornea is injured. Here weexplored the underlying mechanisms for such inter-eye influence.First, we observed an increase in NFκB signaling in the conjunctival epithelium of the opposite eye (p