INVESTIGADORES
TREVANI Analia Silvina
congresos y reuniones científicas
Título:
FEVER-RANGE HYPERTHERMIA IMPROVES THE ANTI-APOPTOTIC EFFECT INDUCED BY LOW PH ON HUMAN NEUTROPHILS PROMOTING A PROANGIOGENIC PROFILE
Autor/es:
DÍAZ, FERNANDO ERRA; DANTAS E; CABRERA, MAIA; CASTRO MAZZA J; ARRIOLA BENITEZ M; DELPINO, MARÍA V; SANJUAN, NORBERTO; TREVANI AS; GEFFNER JR
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión anual Sociedad Argentina de Inmunoogía; 2016
Institución organizadora:
Sociedad Argentina de Inmunoogía
Resumen:
Neutrophils have the shortest lifespan among leukocytes and usually die via apoptosis. We previously reported that low pH, a hallmark of inflammatory processes and solid tumors, moderately delays neutrophil apoptosis. Here we analyzed whether fever-range hyperthermia (39.5°C) was able to modulate the anti-apoptotic effect induced by low pH (pH 6.0). Hyperthermia markedly increased neutrophil survival induced by low pH (anexinV/PI staining/flow cytometry): % apoptosis = 72±5, 45±6, 70±7, and 19±3, for neutrophils cultured for 18 h at pH 7.3/37ºC, pH 6.0/37°C, pH 7.3/39.5ºC, and pH 6.0/39.5°C, respectively (p
