PROTUMORAL PROPERTIES OF NEUTROPHIL EXTRACELLULAR TRAPS (NETS) IN CHRONIC LYMPHOCYTIC LEUKEMIA

PODAZA E; RISNIK D; SABBIONE F; COLADO A; ELIAS E; ALMEJUN B; BEZZARES R; FERNANDEZ GRECCO H; BORGE M; TREVANI AS; GIORDANO M

Congreso; Reunión anual Sociedad Argentina de Inmunoogía; 2016

We previously reported that PMN from CLL patients are prone to release extracellular traps (NETs) in response to 2/#+PVJGRTGUGPVYQTMYGGZVGPFGFVJGUGſPFKPIUWUing ionomycin (1μg/ml) or TNF-D(10 ng/ml) plus LPS (100 ng/ml) to induce NETosis. We found higher concentrations of DNA and increased elastase activity in supernatants from CLL-PMN compared to those from healthy donors (HD) PMN (n=6, p