Chronic Lymphocytic Leukemia (CLL) b cells delay neutrophil apoptosis in vitro

PODAZA E; BORGE M; SABBIONE F; COLADO A; FERNANDEZ GRECCO H; CABREJO M; BEZARES F; TREVANI, AS; GAMBERALE, R; GIORDANO, M

Congreso; Reunión Anual de la SAI; 2014

Sociedad Argentina de Inmunología y Soc. Argentina de Investigación Clínica

Leukemic B cells from CLL patients have the ability to modify macrophage and T lymphocyte functions as a way of promoting their own survival. Recent evidence indicates that neutrophils,the most abundant leukocyte in blood, can also be reprogrammed by tumor cells. The aim of the present study was to determine whether CLL cells are able to modify the viability and functional capacity of neutrophils. Polymorphonuclear cells (>95% neutrophils) isolated from healthy donors (3-4 x 10 6 /ml) were cultured with peripheral blood mononuclear cells from CLL patients (> 93% leukemic B cells,