Apoptosis signaling pathways due to after-effects of acute ethanol exposure in brain cortex.

KARADAYIAN, A.G.; CZERNICZYNIEC A.; LORES ARNAIZ, S.

Buenos Aires

Congreso; Reunión Anual SAIC 2021 Reunión Conjunta SAIC-SAI-AAFE-NANOMED.AR; 2021

Sociedad Argentina de Investigación Clínica

Binge-drinking is the most common alcohol-related disorder whose direct consequence is known as alcohol hangover (AH). This one is defined as a combination of mental and physical symptoms experienced the day after a single episode of heavy drinking, starting when blood alcohol concentration (BAC) approaches zero. We demonstrated that AH induced strong oxidative stress, mitochondrial dysfunction and alterations in nitric oxide (NO) metabolism through the impairment of NMDAR/PSD-95/nNOS pathway in brain cortex synapses.The aim of the present work was to study apoptotic signaling pathways in brain cortex at the onset of AH. Swiss male mice received an i.p. injection of ethanol (3.8 g/kg body weight, AH group) or saline (control group) and were sacrificed 6 h afterwards (BAC=0). Determinations were conducted in mitochondria and lysates from braincortex. Impairment of calcium handling and MPT induction were observed in AH mitochondria (p