The combined administration of alcohol and taurine induces mitochondrial dysfunction at the beginning of alcohol hangover in mouse brain cortex

KARADAYIAN AG; CZERNICZYNIEC A; CARBONE S; CUTRERA RA; LORES ARNAIZ S

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedad Argentina de Investigación Clínica

The combination of alcohol intake and energy drinks is often used as a possible attenuator for hangover symptoms. Alcohol hangover (AH) is the transient state that occurs after an acute ethanol consumption episode and begins when blood alcohol concentration is zero. Particularly, taurine is one of the major components of energy drinks. Therefore, the aim of this work was to evaluate if the combined administration of taurine and alcohol induces brain cortex mitochondrial dysfunction, through determinations of oxygen consumption, mitochondrial membrane potential and hydrogen peroxide production at the beginning of alcohol hangover. Swiss male mice were divided into four experimental groups: control (saline i.p.), taurine (70 mg/kg i.p.), alcohol (3.8 g/kg i.p.) and taurine-alcohol. Data were analyzed by one-way ANOVA. Alcohol hangover group showed 28% and 20% decreases in malate-glutamate state 3 respiration and respiratory control respectively (p