INVESTIGADORES
LORES ARNAIZ Silvia
congresos y reuniones científicas
Título:
Pharmacological regulation of mitochondrial nitric oxide synthase.
Autor/es:
VALDEZ, L.B.; LORES-ARNAIZ, S.; BUSTAMANTE, J.; ALVAREZ, S.; BOVERIS, A.D.; NAVARRO, A.; BOVERIS, A.
Lugar:
París
Reunión:
Congreso; XI Biennial Meeting of the Society for Free Radical Research; 2002
Institución organizadora:
Society for Free Radical Research
Resumen:
The activity of mtNOS can be modulated pharmacologically. Chlorpromazine (one dose, 10 mg/kg, 1h)inhibited 36-48% mitochondrial NO production, increased 25-38% O2 uptake and did not modify the amount of mtNOS protein detected by Western blot. Enalapril (30 mg/kg/day, up to 15 d) increased NO production in kidney, liver and heart mitochondria. In kidney mitochondria, mtNOS activity was 5 times increased and mtNOS protein 125% increased.
