INVESTIGADORES
LORES ARNAIZ Silvia
congresos y reuniones científicas
Título:
Chronic exposure to paraquat induces changes in body weight gain, anxiety like behavior and non olfactory discrimination.
Autor/es:
KARADAYIAN, A.G.; CZERNICZYNIEC, A.; BUSTAMANTE, J.; LORES ARNAIZ, S.; CUTRERA, RA.
Lugar:
Huerta Grande
Reunión:
Congreso; Second Joint Meeting of the Argentine Society for Neuroscience and the Argentine Workshop in Neuroscience; 2010
Institución organizadora:
Sociedad Argentina de Neurociencias
Resumen:
Recently, paraquat (PQ) has been described as a potential environmental
neurotoxin associated with risk for neurodegenerative diseases often developing
after chronic exposure.
It is known that chronic PQ exposure induces changes in the neurobehavior
compromising the motor and sensitive functions. The aim of this study was to
evaluate the possible cognitive and sensitive changes weekly in an experimental
model of PQ toxicity during a month. Materials and Methods: SD female rats
(n=12) were divided in two groups which received either PQ (10 mg/Kg i.p.) or
saline once a week during four weeks. Body weight gain, anxiety like behavior
and non social olfactory discrimination were monitored throughout the treatment.
Results: PQ treated and control mice gained body weight on average. However,
the body weight gain of the PQ-treated group was lower than control groups in
the last week (p<0.01). Together with this, PQ animals presented a significant
increase in anxiety like behavior from the first injection (p<0.05) and a reduction
of the olfactory discrimination when animals were exposed to a novel scent from
the second injection (p<0.05 t-student
paired test). This research suggests that PQ treatment induces behavioral changes that could be involved in the first steps of
Parkinsonism.