INVESTIGADORES
LORES ARNAIZ Silvia
capítulos de libros
Título:
Nitric oxide and mitochondrial function in neuronal aging and plasticity.
Autor/es:
LORES-ARNAIZ, S.; BUSTAMANTE, J.
Libro:
Free Radical Pathophysiology
Editorial:
Research Signpost
Referencias:
Lugar: Trivandrum; Año: 2008; p. 329 - 343
Resumen:
Nitric oxide has been postulated as a signaling
molecule in different neuronal processes such as
neural development, axonal regeneration and synaptic
plasticity. Nitric oxide has also been shown to exert a
modulatory action on mitochondrial respiratory chain
activity.
Normal brain aging is associated with a decline in
neuronal activity, which leads to a progressive
impairment in cognition and memory. Changes in
nitric oxide synthase activity and expression and in
mitochondrial function in association with the aging process, will be
described.
The participation of nitric oxide in mechanisms of neuronal plasticity has
been extensively studied. Exposure to enriched environments leads to an
increased nitric oxide synthase activity and expression, mediated by nNOS,
thus contributing to the prevention of the age-dependent impairment of
cognition. Considering that synaptic transmission requires a considerable
energy demand, mitochondrial function seems to play a essential role in
neuronal plasticity.