Nitric Oxide Accumulation is Required to Protect Against Iron-Mediated Oxidative Stress in Frataxin-Deficient Arabidopsis

MARTIN, M.; RODRIGUEZ-COLMAN, M. J.; GÓMEZ-CASATI, D.; LAMATTINA, L.; EDUARDO JULIAN ZABALETA

FEBS LETTERS

ELSEVIER SCIENCE BV

Año: 2009 vol. 583 p. 543 - 548

0014-5793

frataxin is essential for cellular iron (Fe) homeostasis and survival during oxidative stress. In plants,frataxin deficiency causes increased reactive oxygen species (ROS) production and high sensitivity tooxidative stress. In this work we show that a knock-down T-DNA frataxin-deficient mutant of Arabidopsisthaliana (atfh-1) contains increased total and organellar Fe levels. Frataxin deficiency leadsalso to nitric oxide (NO) accumulation in both, atfh-1 roots and frataxin null mutant yeast. Abnormallyhigh NO production might be part of the defence mechanism against Fe-mediated oxidativestress