INVESTIGADORES
GOLOMBEK Diego Andres
artículos
Título:
Circadian dysregulation in Parkinson's disease
Autor/es:
VIDENOVIC, ALEKSANDAR; GOLOMBEK, DIEGO
Revista:
Neurobiology of Sleep and Circadian Rhythms
Editorial:
Elsevier Inc
Referencias:
Año: 2017 vol. 2 p. 53 - 58
ISSN:
2451-9944
Resumen:
Parkinson´s disease (PD) is the second most common neurodegenerative disorder that affects over one million individuals in the US alone. PD is characterized by a plethora of motor and non-motor manifestations, resulting from a progressive degeneration of dopaminergic neurons and disbalance of several other neurotransmitters. A growing body of evidence points to significant alterations of the circadian system in PD. This is not surprising given the pivotal role that dopamine plays in circadian regulation as well as the role of circadian influences in dopamine metabolism. In this review we present basic and clinical investigations that examined the function of the circadian system in PD.
