INVESTIGADORES
ALONSO Daniel Fernando
artículos
Título:
Rho GTPases as therapeutic targets in cancer and other human pathologies
Autor/es:
PL MENNA; GA CARDAMA; MJ COMIN; DF ALONSO; DE GOMEZ
Revista:
MEDICINA (BUENOS AIRES)
Editorial:
MEDICINA (BUENOS AIRES)
Referencias:
Año: 2010 vol. 70 p. 555 - 564
ISSN:
0025-7680
Resumen:
Rho GTPases are a key protein family controlling the transduction of external signals to cytoplasmatic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases. The aim of this review is to describe the cellular functions regulated by these proteins with focus on the molecular mechanism involved. We also address the role of Rho GTPases in the development of different human diseases such as cancer. Finally, we describe different experimental therapeutic strategies with Rho GTPases as molecular targets.
