Wearable biosensors for simultaneous detection of glucose and ascorbic acid in noninvasive biofluids – A review

GONZÁLEZ, JULIETA C.; MADRID, ROSSANA E.

San Juan

Congreso; XXIII CONGRESO ARGENTINO DE BIOINGENIERÍA Y XII JORNADAS DE INGENIERÍA CLÍNICA; 2022

Sociedad Argentina de Bioingeniería

The increasing prevalence of a growing population, and aging and chronic diseases that continually increase health costs, cause the health care system to undergo a transition from the traditional hospital-centered system to an individual-centered one. Wearable sensors are becoming widespread in biomedical monitoring systems, enabling continuous measurement of critical biomarkers for disease monitoring through the assessment of biological fluids such as saliva, tears, and sweat. One of the substances of interest to monitor is ascorbic acid (AA) (vitamin C), since it is not synthesized by the body and its ingestion is necessary. Numerous electrochemical biosensors have been developed for glucose detection, where AA is an interferent. This work carries out a literature review of the sensors developed for the simultaneous detection of glucose and AA in noninvasive biofluids. A metaanalysis of the main materials, methods and platforms used in portable biosensors was carried out. It was found that the most promising biosensors to simultaneously measure these analytes correspond to electrochemical biosensors and their detection in sweat.