Impact of aerobic training on the metabolism of the adipose tissue of spontaneously hypertensive rats

CAVALLI F; GODOY COTO J; PEREYRA E; VILLAGARCÍA H; YEVES A; FRANCINI F; ENNIS I; CALDIZ CI

Simposio; XXXV Reunión Anual SCHCF 2020 en conjunto con la reunión ALACF. (Sociedad Chilena de Ciencias Fisiológicas (SCHCF) y Council de la Asociación Latinoamericana de Ciencias Fisiológicas (ALACF); 2020

Introduction: cardiovascular diseases are the first cause of death in Argentina and worldwide, being hypertension the main modifiable risk factor. There is an association between hypertension, insulin resistance (IR), and oxidative stress (OS). Interestingly, physical training delays the progression of cardiovascular disease and improves insulin sensitivity, possibly involving modifications in adipose tissue (AT).Objective: To determine the effects of aerobic training (Tr) on IR, OS, and AT phenotype in spontaneously hypertensive rats (SHR).Methodology: SHR were randomly assigned to a sedentary group (S) or subjected to a swimming routine for 8 weeks (Ex). OS was determined by TBARS and O2- production measured by the lucigenin method in AT. To study the insulin response, Glut4 expression and phosphorylation were measured in adipocyte membrane fractions and a glucose tolerance curve (GTC) was performed. Changes in the AT phenotype were analyzed in histological sections by light microscopy. Results are expressed as mean±SE (n) and compared by T-test, considering p