Maternal intake of alpha lipoic acid prevents development of symptoms associated with a fructose-rich diet in the male offspring in Wistar rats

RABAGLINO B; JOSÉ MOREIRA-ESPINOZA MJ; LAGARES C; GARAY MI ; QUIROGA P; PASQUALINI ME; FRANCINI F; BELTRAMO D

Journal of Developmental Origins of Health and Disease

Cambridge University Press

Año: 2021 p. 758 - 767

2040-1744

The hypothesis was that maternal intake of the anti-oxidant alpha lipoid acid (ALA), during thedevelopmental period of the hypothalamic orexigenic neurons, causes a permanent beneficial effect in offspring metabolism. Pregnant Wistar rats were fed with standard diet (food) + ALA (0.4% wt/wt) from day 14 of gestation to day 20 of lactation (n=4) or food (n=4). At three months of age, male offspring born from ALA-fed rats or controls (CT) were randomly assigned to be fed with food + 10% fructose solution in drinking water (F) or food + tap water (C); resulting in 4 groups: ALAF, ALAC, CTF and CTC (n=5/group). Food intake and body weight (BW) were measured twice a week for 31 days. Metabolites? levels in blood, mRNA expressions of Npy, Agrp (hypothalamus), Fasn, Srebf1, Ppard and Pparg (liver), and the antioxidant capacity of the liver were determined. Results significance was set at p