Modulation of diabetes by natural products and medicinal plants via incretins

RIOS JL; ANDUJAR I; SCHINELLA G; FRANCINI F

PLANTA MEDICA

GEORG THIEME VERLAG KG

Año: 2019 p. 825 - 839

0032-0943

Incretins are metabolic hormones released after a meal thatincrease insulin secretion from pancreatic β-cells. The twomain incretins are the intestinal peptides glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide.Both induce a decrease in glycemia, slow down the absorptionof nutrients, and are inactivated by the enzyme dipeptidylpeptidase-4. Recently, incretin-based therapies have becomea useful tool to treat diabetic patients, and different studieshave focused on the identification of glucagon-like peptide-1receptor agonists, including those of natural origin. This review focuses on the new findings of medicinal plants and natural products as possible active agents on the potentiation ofincretin receptor signaling. Among these, soluble fiber fromspecies of Plantago and guar gum show promising effects, iridoid derivatives are relevant activators of incretin receptors,and derivatives of cyanidin, especially diglycosylated ones,are an interesting source of dipeptidyl peptidase-4 inhibitors.