3D printing of hydrogel inks containing PHBV microparticles.

PACHECO, EVELINA; PÉREZ RECALDE, MERCEDES; ARÁOZ, BEATRIZ; HERMIDA, ELIDA

Dresden

Conferencia; 7th. International Conference on Cellular Materials; 2022

3D printing has widely increased the development of cellular materials that emulate the extracellular matrix of different tissues [1]. Inks for 3D printing must fulfill certain biological and mechanical requirements: to be biocompatible and biodegradable, to have a shear-thinning behavior, to show at least 0,90 of printability, and to give scaffolds with similar mechanical properties to the tissue to be replaced. Furthermore, the addition of a drug delivery systems (DDS) to a scaffold is under development, seeking potential applications in pharmacology [2]. In this work, a sodium alginate-gelatin hydrogel with poly (hydroxybutyrate-co-hydroxyvalerate) (PHBV) microparticles was employed to produce 3D printed scaffolds.Results suggest that microparticles with alginate-gelatine hydrogel can be combined giving inks accurate for the application in 3D printing, and the microparticles produce changes in the microstructure both in ink form and in the scaffold form. 30 mg MP in this system is highlighted for DDS application for soft tissues.