Development of a Physiologically based pharmacokinetic model to predict the superparamagnetic iron oxide nanoparticles (SPIONS) accumulation in vivo

A.H. SILVA; E. LIMA JR.; M. VASQUEZ MANSILLA; R.D. ZYSLER; M.L. MOJICA PISCIOTTI; C. LOCATELLI; R.K.R. RAJOLI; A. OWEN; T.B. CRECZYNSKI-PASA; M. SICCARDI

Ribeirão Preto, São Paulo

Congreso; 10th International Congress of Pharmaceutical Sciences - CIFARP 2015; 2015

Asociacion Brasileira de Ciencias Farmaceuticas

Superparamagnetic iron oxidenanoparticles (SPIONs) have been widely used for medical applications such asmagnetic resonance imaging, cell labeling and cancer cells treatments through hyperthermia.All these biomedical applications require a fully understand about thedistribution of SPIONs in the human body. Physiologically-based pharmacokinetic(PBPK) modeling is a mathematical representation of physiological andanatomical processes influencing the distribution of nanoparticles (NPs). Theaim of this study was to develop a PBPK model to predict the pharmacokineticsof SPIONs in mice and humans. The PBPK model was developed including elevencompartments connected through regional blood flow and NPs excretion wassimulated through the biliary and urinary routes. The distribution and accumulationof SPIONs in organs were simulated taking into account their penetrationthrough capillary walls and their active uptake by specialized macrophages inthe liver, spleen and lungs.