Influence of magnetite concentrations of the physicochemical and photophysical properties of a novel octasubstituted zinc(II) phthalocyanine incorporated into liposomes

VIRGINIA DIZ; ALAN SZALAI; ROBERTO D. ZYSLER; JOSEFINA AWRUCH; LELIA E. DICELIO

Córdoba

Encuentro; XI Encuentro LatinoAmericano de Fotoquímica y Fotobiología (XI ELAFOT); 2012

ELAFOT

The photophysical properties of 2,3,9,10,16,17,23,24-octakis[(N,N-dimethylaminoethylsulfanyl)]phthalocyaninatozinc(II) (S1), incorporated into nanoparticles of magnetite (Fe3O4) and liposomes of phosphatidylcholine were studied in order to obtain magneto-liposomes as potential photosensitizer carriers for photodynamic therapy. The concentration of magnetite incorporated in LUV liposomes was evaluated in the samples before and after its filtration obtained by using membranes of 50 nm pore diameter. The well-dispersed liposomes were characterized by Dynamic Light Scattering (DLS) and Transmission Electronic Microscopy (TEM). The average diameter for DLS studies was 100 nm; a reproducible unimodal population of LUV liposomes was obtained. The incorporation of magnetite nanoparticles was establish from measurements by Atomic Absorption Spectrophotometry (ASS) and the saturation magnetization hysteresis curves(250K). Fluorescence and singlet molecular oxygen quantum yields were performed in liposomes and in magneto-liposomes. S1 liposomes values were in order of Phif = 0.13 and Phid = 0.51, whereas S1 in magneto-liposomes were Phif = 0.04 and Phid = 0.06 respectively.