Photophysics of a novel octasubstituted zinc(II) phthalocyanine incorporated into magneto-liposomes

VIRGINIA EMILSE DIZ; JULIO LAURENZA; ROBERTO ZYSLER; JOSEFINA AWRUCH; LELIA E. DICELIO

Mendoza

Congreso; 21st Inter-American Photochemical Society (I-APS) Conference; 2011

Inter-American Photochemical Society (I-APS)

The photophysical properties of 2,3,9,10,16,17,23,24-octakis[(N,N-dimethylaminoethylsulfanyl)]phthalocyaninatozinc(II) (S1), incorporated into nanoparticles of magnetite (Fe3O4) and liposomes of phosphatidylcholine were studied in order to obtain magneto-liposomes as potential photosensitizer carriers for photodynamic therapy. Fluorescence and singlet molecular oxygen quantum yields were performed in liposomes and in magneto-liposomes. S1 liposomes values were in order of fiF = 0.13 and fiΔ = 0.51, whereas S1 in magneto-liposomes were fiF = 0.04 and fiΔ = 0.06 respectively. The well-dispersed liposomes were characterized by Static Light Scattering (SLS) and Transmission Electronic Microscopy (TEM). The average diameter for SLS studies was 275 nm; a reproducible unimodal population of LUV liposomes was obtained. The incorporation of magnetite nanoparticles was established from the saturation magnetization hysteresis curves (250K); the same results were obtained for both magnetic nanoparticles and magneto-liposomes.