β-cyclodextrin coating: improving biocompatibility of magnetic nanocomposites for biomedical applications

MARIELA A. AGOTEGARAY; MARÍA GABRIELA BLANCO; A. CAMPELO; E. GARCÍA; R.D. ZYSLER; V. MASSHEIMER; M.J. DE ROSA; V.L LASSALLE

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

SPRINGER

Lugar: Berlin; Año: 2020 vol. 31 p. 22 - 22

0957-4530

The role Beta-cyclodextrin (βCD) on improving biocompatibility on healthycellular and animal models was studied upon a formulation obtained from thedevelopment of a simple coating procedure. The obtained nanosystems werethoroughly characterized by FTIR, TGA, atomic absorption spectroscopy, dynamiclight scattering and zeta potential, TEM/HR-TEM and magnetic properties. βCD might interact with the magnetic core throughhosting OA. It is feasible that the nanocomposite is formed by nanoparticles ofMG@OA dispersed in a βCD matrix. Theevaluation of βCD role onbiocompatibility was performed on two healthy models. To this end, in vivostudies were carried out on Caenorhabditis elegans. Locomotion and progeny wereevaluated after exposure animals to MG, MG@OA, and MG@OA-βCD (10 to 500 μg/mL). The influence of βCD on cytotoxicity was explored in vitro on healthy rat aorticendothelial cells, avoiding alteration in the results derived from the use oftransformed cell lines. Biological studies demonstrated that βCD attaching improves MG biocompatibility.