Vascular Function and Heart Rate Variability in Mothers of Children with Low Birth Weight

PERAL DE BRUNO MARIA.; JOO TURONI CLAUDIO; CHAHLA ROSSANA; CHAILA ZULEMA; BAZAN DE CASELLA CRISTINA

Buenos Aires

Congreso; Meeting of Latin American Pediatric Endocrinology Society (SLEP); 2016

Latin American Pediatric Endocrinology Society (SLEP)

Introduction: It is known that low birth weight (LBW) is associatedwith increased risk of cardiovascular disease (CVD) inadult life. The heart rate variability (HRV) results from a balancebetween sympathetic/parasympathetic systems and reflects our capacityto adapt to changing situations. It was demonstrated thatHRV is decreased in many CVD. New researches show that theBPN may be result of multiple factors both of the child and themother that could negatively impact on the fetal growth environment.Objective: To study endothelial function (EF) and HRV bynon-invasive methods and its relationship with CVD risk markersin mothers of children with a history of LBW.Method: Mothers of children with or without LBW (controlgroup) were studied. Waist circumference, height, weight, systolic/diastolic blood pressure (SBP/DBP), glucose, insulin and lipid profilewere determined. EF was measured by pulse wave plethysmographyevaluating flow-mediated vasodilatation. HRV (variation inthe beat-to-beat interval) was analyzed by standard deviation of beat-to-beat or NN intervals (SDNN); spontaneous variability ofheart rate (percentage of consecutive beats that differ more than50 ms: pNN50) and the product of the maximum HR and SBP(MHRxSBP).Results: In mothers, we found that SDNN was significantly correlatedwith the weight of children at birth (Pearson r = 0.5634;IC50%: 0.1739 to 0.8004; p < 0.01, n = 21). Also in mothers, thepercentage or number of children with LBW was negatively correlatedwith HRV. When comparing the group of mothers of childrenwith LBW and control group, there were no differences in age, anthropometricparameters and laboratory variables and SBP/DBP inboth groups. However mothers of children with LBW presented adecreased endothelial function (1.86 ± 6.6% HR n = 13) in contrastwith mothers of control group (19.4 vs. 5.9; n = 8; p < 0.02).Conclusions: We observed for the first time that the mothersof children with a history of LBW, although have similar characteristicin her anthropometric and biochemical parameters andblood pressure in relation with control group, these mothers havea decreased endothelial function as well as a minor HRV. Thesefacts indicate that the BPN could be associated with early changesof the autonomic adaptive axis mothers.